Unit 1: Pharmaceutical Chemistry
Introduction to pharmacy, career in pharmacy, codes of pharmaceutical ethics, importance of pharmaceutical chemistry, pharmacopoeia and its history (IP, BP, USP, NF).
Drug and cosmetic act with special reference to schedule M, GMP, GLP, GCP, USFDA, NDA, clinical trial.
Concept of quality and total quality management, quality assurance and quality control, IPQA, IPQC.
Documentation and maintenance of record, intellectual property rights, patents, trademark, copyright, patent act.
Unit 2: Pharmacognosy
Definition, history, scope and development of Pharmacognosy.
Classification and Sources of drugs: classification of drugs, sources and uses of natural drug products, biological (plants, animals and microbes), geographical, marine and mineral sources.
Drug Receptors: Introduction to drug receptors, nature of drug receptors, different bonding involved in drug-receptor interaction, drug receptor theories.
Drug absorption: routes of drug administration, absorption of drugs and factors affecting absorption.
Unit 3: Molecular Modeling and Drug Design
Drug design and development an overview, analogues and prodrugs structure and activity relationship between chemical (SAR), factors governing drug design, approaches to drug design, receptor site theory.
Introduction to combinatorial synthesis in drug discovery, factors affecting bioactivity.
QSAR-Free-Wilson analysis, structure–biological activity Hansch analysis, relationship between Free-Wilson analysis and Hansch analysis.
Unit 4: Antibiotics and Antibacterials
Introduction, Antibiotic β-Lactam Type – Penicillin, Cephalosporins, Antitubercular – Streptomycin, Broad Spectrum Antibiotics – Tetracyclines, Anticancer – Dactinomycin (Actinomycin D)
Unit 5: Antifungal and Non-steroidal Anti-inflammatory Drugs
Antifungal: Polyenes, Antibacterial – Ciprofloxacin, Norfloxacin, Antiviral – Acyclovir
Antimalarials: Chemotherapy of Malaria SAR, Chloroquine, Chloroguanide and Mefloquine.
Non-steroidal Anti-inflammatory Drugs: Diclofenac Sodium, Ibuprofen and Netopam.
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